CovidV2, new, Analysis, bibRecord, 000283

Molecular basis of COVID-19 relationships in different species: a one health perspective.

Identifieur interne : 000283 ( new/Analysis ); précédent : 000282; suivant : 000284

Molecular basis of COVID-19 relationships in different species: a one health perspective.

Auteurs : Bruno Tilocca [Italie] ; Alessio Soggiu [Italie] ; Vincenzo Musella [Italie] ; Domenico Britti [Italie] ; Maurizio Sanguinetti [Italie] ; Andrea Urbani [Italie] ; Paola Roncada [Italie]

Source :

Microbes and infection [ 1769-714X ] ; 2020.

RBID : pubmed:32194253

Abstract

Outside the Hubei province, China, the mild form of infection and the progressive recover of the COVID-19 patients suggest the intervention of "unconventional" biological mechanisms worthy of attention. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we hypothesized that past contact with infected dogs shield humans against the circulating SARS-CoV-2. Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province. Nevertheless, further experimental studies are desired for a confidential evaluation of the postulated hypotheses.

DOI: 10.1016/j.micinf.2020.03.002
PubMed: 32194253

Affiliations:

Italie

Links to Exploration step

pubmed:32194253

Le document en format XML

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<front><div type="abstract" xml:lang="en">Outside the Hubei province, China, the mild form of infection and the progressive recover of the COVID-19 patients suggest the intervention of "unconventional" biological mechanisms worthy of attention. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we hypothesized that past contact with infected dogs shield humans against the circulating SARS-CoV-2. Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province. Nevertheless, further experimental studies are desired for a confidential evaluation of the postulated hypotheses.</div>
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Molecular basis of COVID-19 relationships in different species: a one health perspective.

Molecular basis of COVID-19 relationships in different species: a one health perspective.

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